Image courtesy Cinelli lab
Head Center for Surgical Research and Research Laboratory Department of Trauma
University Hospital Zurich and University of Zurich
Research Focus: The main research focus of our research group is the establishment, characterization and analysis of pluripotent stem cells (ESCs, iPSCs) and in particular the study and implementation of their potential for therapeutic and medical applications. One of the main issues with the use of stem cells for clinical applications is the ability to maintain these cells outside of the body (in vitro) in a self-renewing pluripotent and/or multipotent state and to differentiate them to specific cell types. Our work focuses in understanding the molecular mechanisms involved in the regulation of pluripotency and differentiation in preimplantation embryos, embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs) and mesenchymal stromal cells (MSCs). Furthermore, we develop and optimize tissue engineering approaches for bone regeneration with pluripotent (iPSCs) and multipotent stem cells.
Methods: Embryonic stem cells, IPSCs, Mesenchymal Stromal cells, single cell analysis, CyTOF, in vivo models.
Keywords: pluripotency, regenerative medicine, bone
Topics: Pluripotency, bone regeneration