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iPSC-based research in Zurich

Muscle biology


Induced myogenic progenitor cells stained for skeletal muscle stem, progenitor and differentiated cell markers

courtesy of Bar-Nur lab



Ori Bar-Nur


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Prof. Dr. Ori Bar-Nur 

Assistant Professor of Regenerative and Movement Biology

Institute of Human Movement Sciences and Sport, Department of Health Sciences and Technology, ETH Zurich

Research Focus: The primary long-term goal of the Regenerative and Movement Biology lab is directed towards developing stem cell-based therapeutic approaches to treat degenerative loss of muscle mass. To this end, we employ direct lineage reprogramming approaches to convert somatic cells into regenerative-competent myogenic stem and progenitor cells suitable for potential therapies of muscle diseases in animal models. In addition, our lab works on generating muscle stem cells utilizing “blastocyst complementation”, a technique which purposes to produce organs, tissues or cells in animal chimeras via microinjection of induced pluripotent stem cells (iPSCs) into genetically compromised blastocyst-stage embryos. Using this system, we generate both intraspecies chimeras (i.e. mouse-mouse)  and interspecies chimeras (i.e. rat-mouse) to assess the feasibility of iPSCs to contribute to the production of myogenic stem cells that can be harnessed to treat muscular dystrophies in rodent models.

Methods: Direct lineage conversion utilizing small molecules and transcription factors, isolation and propagation of skeletal muscle stem cells, CRISPR/Cas9 genome editing of genetic mutations that manifest in muscular dystrophies, muscle stem cell transplantation, generation of mouse and rat iPSCs, generation of intraspecies and interspecies chimeras, next generation sequencing assays of skeletal muscle cells

Keywords: Skeletal muscle regeneration, muscle stem cells, direct lineage reprogramming, Duchenne muscular dystrophy, iPSCs, blastocyst complementation

Topics: Muscle Biology, Muscle Diseases

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